Microsphere & Nanoparticle-based Drug Delivery Systems

Controlled-release Delivery
Targeted and Site-Specific Delivery
optimized for...
Parenteral Delivery Systems
Intranasal Delivery Systems
Oral Delivery Systems

Stemming from our microparticle expertise, PolyMicrospheres has been at the forefront of microencapsulation and advanced drug delivery technologies.  Working with APIs from Eli Lilly, Merck, US Army, and others, we have developed drug delivery systems that provided the controlled-release of drugs and other bioactive agents for several weeks and even months.  

We specialize in the design and development of microsphere and nanoparticle-based drug delivery systems, including optimization, rapid feasibility stuides, evaluation and in vitro release studies, scale-up and manufacturing (from grams to kilogram quantities).

Our advantage:  UNIFORMITY
  • Uniform particle size

  • Uniform drug loading

  • Uniform surface morphology

​Uniform release

Key features
  • Release profiles ranging from days to months

  • Tailored to various modes of administration:  Parenteral (IV, IM, subcutaneous), intranasal, and oral

  • Microencapsulation technologies to allow active ingredients to withstand or pass through biological barriers, such as the digestive or blood brain barrier

    • For oral delivery, the active ingredients are protected from degradation and conformational changes in the acidic environment of the stomach​

  • Site specific - the drug delivery system can be retained at the specified site for continuous delivery

Parameters we can optimize

Our expertise allows us to optimize the following parameters, based on the active agent and mode of administration used in your application.  

  • Release kinetics and efficacy

  • Various biodegradable and biocompatible matrix materials

  • Surface properties of the matrix

  • Particle size (ranging from 50nm to 500μm)

  • Desired drug loading

Drug candidates
  • Water-soluble and water-insoluble drugs

  • Small molecules to large proteins

  • Recombinant peptides and proteins

  • Chemotherapeutics

  • Other pharmaceutical compounds

Recent work