Advanced Nanotechnologies and PolyMicrospheres, Divisions of Vasmo, Inc., are leaders in developing Nanoparticle-based and Microparticle-based Delivery Systems with embedded chemotherapeutics and other pharmaceutical compounds for the controlled-release delivery of drugs to affected tissues over an extended period.
Advanced
Nanotechnologies is specialized in developing cutting-edge nanoparticle
technologies for the new millennium at the molecular level.
Advanced Nanotechnologies is devoted to fostering the development of
targeted drug delivery systems.
We are also committed to providing development of diagnostic devices for
the early detection of diseases.
Our emphasis has been on the innovation of new
products through dedicated research.
Design
and development of nanoparticle-based drug delivery systems and medical
& diagnostic devices
Wide
range of biodegradable and biocompatible matrix materials
Variety
of particle sizes ranging from 40 nm to 1000 nm
Release
rates from days to weeks
Optimization
Rapid
feasibility studies
Evaluation
and in vitro
release studies
Scale-up and Manufacturing
The goal of our company is to work with our customers, collaborators, and
strategic partners in adapting our technologies to their specific applications.
We design and develop Nanoparticle Delivery Systems with embedded
chemotherapeutics and other pharmaceutical compounds for the controlled delivery
of drugs to affected tissues over an extended period.
We develop antibody and other moiety-bound Nanoparticle Delivery Systems
embedded with chemotherapeutic drugs to achieve targeted and extended delivery
to cancer cells. We also
develop surface-modified Nanoparticle Delivery Systems for better cellular
penetration and distribution of the nanospheres in the tumor cells.
Although
there are several potent anticancer drugs currently on the market, their use is
limited because of toxicity to normal tissues.
By microencapsulating drugs in nanosphere matrices, we can control the
release of drugs without reaching toxic levels.
By further targeting the drugs to be concentrated in the tumor tissue, we
can selectively reduce toxicity with a concurrent increase in therapeutic index.
The Nanoparticle Delivery Systems offer the advantage of targeted or
site-specific delivery of chemotherapeutics and other drugs to affected cells
over an extended period, thereby increasing efficacy while reducing toxic side
effects.
We use many biodegradable and/or biocompatible matrix materials to
develop the delivery systems. We
work with water-insoluble and water-soluble drugs for various applications.
Our Nanoparticle Delivery Systems provide optimum nanoparticle size and
surface properties with adequate drug loading for targeting and accumulation
into the affected tissues. The benefits include maximum cellular penetration and a
continuous drug release from days to weeks,
leading to maximum activity with minimum toxicity.
We will work closely with your staff to design and develop the delivery system that provides you with exceptional performance and product capabilities. During and after the development of the product, we help our customers not only in consultation but also with hands-on support. We look forward to providing your organization with a truly competitive edge.
Controlled-release
delivery systems
Extended-release
systems
Targeted
delivery systems
Site-specific
delivery systems
Nanoparticle-based
medical devices
Diagnostic
Systems for early detection of diseases
Parenteral
delivery systems
Chemotherapeutic
delivery systems
Intranasal
and inhalation delivery systems
Delivery
to the central nervous system
Ophthalmic
delivery systems
Dental
delivery systems
Transdermal
delivery formulations
Animal health formulations
Controlled-release
technology
Extended-release
delivery
Targeted
delivery
Site-specific
delivery
Microencapsulation
and matrix technologies
Emulsification
and solvent evaporation
Emulsification
and solvent extraction
Complex
coacervation
Seeded
emulsion polymerization
Interfacial
polymerization
Nanoparticle
technologies
Lamination/coating
of nanosystems
Surface modifications
Water-insoluble
drugs
Water-soluble
drugs
Chemotherapeutic
agents
Other
pharmaceutical compounds
Peptides
Proteins
Hormones
Oligonucleotides
Nucleic
acids
Steroids
Antibiotics
Vaccines
Polylactide
(PLA)
Polyglycolide
(PGA)
Lactide-glycolide
copolymers (PLG)
Polycaprolactone
Lactide-caprolactone
copolymers
Polyhydroxybutyrate
Polyalkylcyanoacrylates
Polyanhydrides
Polyorthoesters
Proteins: albumin, collagen, gelatin
Polysaccharides: dextrans, starches
Acrylate
polymers and copolymers:
methyl
methacrylate, methacrylic acid,
hydroxyalkyl
acrylates and methacrylates,
ethylene
glycol dimethacrylate,
acrylamide,
bisacrylamide
Cellulose-based
polymers
Ethylene
glycol polymers and copolymers
Oxyethylene
and oxypropylene polymers
Poly(vinyl
alcohol) and Polyvinylacetate
Polyvinylpyrrolidone and polyvinylpyridine