PolyMicrospheres and Advanced Nanotechnologies, Divisions of Vasmo,
Inc., are leaders in developing Microparticle and Nanoparticle-based Drug Delivery
Systems with embedded chemotherapeutics and other pharmaceutical compounds for
the controlled-release delivery of drugs to affected tissues over an extended
period.
PolyMicrospheres, widely recognized for designing and developing
microsphere-based drug delivery systems, remains at the forefront of
microencapsulation and controlled-release technologies.
Since its founding in 1990, PolyMicrospheres has been dedicated to
providing development of novel drug delivery systems to pharmaceutical, medical
device, and biotechnology industries.
Advanced Nanotechnologies is specialized in
developing cutting-edge nanoparticle technologies for the new millennium at the
molecular level. Advanced
Nanotechnologies is devoted to fostering the development of targeted drug
delivery systems
and
diagnostic devices for the early detection of diseases.
Our emphasis has been on the innovation of new products through dedicated research. The precision and accuracy of our techniques, together with GMP and ISO 9001 certified manufacturing practices, provide the highest quality and constantly reproducible products. We are equipped with numerous custom-designed glass/glass-lined reactors and process controllers in our 40,000 sq. ft. facility to produce from grams to kilogram quantities of microsphere-based products in a single production run.
Design
and development of microsphere-based
and nanoparticle-based drug delivery systems and medical devices
Wide
range of biodegradable and biocompatible matrix materials
Variety
of particle sizes ranging from 40 nm to 1000 µM
Release
rates from days to weeks to months
Optimization
Rapid
feasibility studies
Evaluation
and in vitro
release studies
Scale-up and Manufacturing
The goal of our company is to work with our customers, collaborators, and
strategic partners in adapting our technologies to their specific applications.
We design, develop, and manufacture novel microsphere-based and
nanoparticle-based drug delivery systems to provide release profiles from a few
days to several weeks. Using
state-of-the-art facilities and the most-innovative microencapsulation and
matrix technologies, we develop and manufacture a complete range of delivery
systems with a variety of particle sizes, surface chemistries, and release
profiles.
The use of
microsphere-based therapy allows drug release to be carefully tailored to the
specific treatment through the choice and formulation of various drug-polymer
combinations. The total dose of
medication and the kinetics of release are variables that can be manipulated.
Using innovative microencapsulation technologies and by varying the
copolymer ratio and molecular weight, PolyMicrospheres develops the optimal
drug delivery system to provide a release profile from a few days to
many weeks. Microsphere-based systems increase the life-span of active constituents and
control the release of bioactive agents. The
release matrix regulates the plasma concentration peaks and reduces toxicity and
other side effects.
Our Drug Delivery Systems provide optimum particle size and surface
properties with adequate drug loading for targeting and accumulation into the
affected tissues. The Microparticle
and Nanoparticle Delivery Systems offer the advantage of targeted or
site-specific delivery of chemotherapeutics and other drugs to affected cells
over an extended period, thereby increasing efficacy while reducing toxic side
effects.
Controlled-release
delivery systems
Extended-release
systems
Time-release
dosage forms
Targeted
and site-specific delivery systems
Microsphere/nanosphere-based
medical devices
Injectable
microspheres and nanospheres
Implantable
microbeads
Laminated/coated
microsystems and nanosystems
Microemulsions
Hydrogels
Parenteral
delivery systems
Chemotherapeutic
delivery systems
Intranasal
and inhalation delivery systems
Delivery
to the central nervous system
Ophthalmic
delivery systems
Oral
dosage forms -- extended release,
enteric formulations, taste masking
Dental
delivery systems
Transdermal
delivery formulations
Fragrance
release formulations
Flavor
release formulations
Color
containment or release systems
Animal health formulations
Controlled-release
technology
Extended-release
delivery
Targeted
and site-specific delivery
Drug
stabilization and solubilization
Microencapsulation
and matrix technologies
Emulsification
and solvent evaporation
Emulsification
and solvent extraction
Complex
coacervation
Protein
gelation
Spray
drying
Microparticle
and nanoparticle technologies
Lamination/coating
of microparticles
Surface
modifications
Seeded
emulsion and interfacial polymerizations
Dispersion
and suspension polymerizations
Micelles and Microemulsions
Water-insoluble
drugs
Water-soluble
drugs
Chemotherapeutic
agents
Other
pharmaceutical compounds
Peptides
Proteins
Hormones
Oligonucleotides
Nucleic
acids
Steroids
Antibiotics
Vaccines
Polylactide
(PLA)
Polyglycolide
(PGA)
Lactide-glycolide
copolymers (PLG)
Polycaprolactone
Lactide-caprolactone
copolymers
Polyhydroxybutyrate
Polyalkylcyanoacrylates
Polyanhydrides
Polyorthoesters
Proteins: albumin, collagen, gelatin
Polysaccharides: dextrans, starches
Acrylate
polymers and copolymers:
methyl
methacrylate, methacrylic acid,
hydroxyalkyl
acrylates and methacrylates,
methylene
glycol dimethacrylate,
acrylamide,
bisacrylamide
Cellulose-based
polymers
Ethylene
glycol polymers and copolymers
Oxyethylene
and oxypropylene polymers
Poly(vinyl
alcohol) and Polyvinylacetate
Polyvinylpyrrolidone and polyvinylpyridine